Endocrine Abstracts

When pituitary MRI show a typical imaging of adenoma, it is agreed that transsphenoidal surgery is the reference treatment with remission achieved in about 80% of patients. If MRI is negative or inconclusive, some authors consider that the results of surgery are less successful, and propose medical treatment as a first line therapy, despite a disease control rate between 30 and 70%. Since 1990, our center chose to systematically explore patients with ACTH dependent hypercortic...

Introduction: In patients with primary aldosteronism (PA) international consensus claim that adrenal venous sampling (AVS) performs better than CT scan in determining lateralization of aldosterone secretion. The SPARTACUS study has however reported similar performances for lateralization by CT scan and AVS in patients with PA and a unilateral adrenal mass. The standard procedure for AVS uses cortisol values to validate the selectivity of catheterization and to normalize the al...

Context: To date ten publications reporting only 16 patients with pituitary aggressive tumors or carcinomas treated with temozolomide are available. Expression of O6-methylguanine-DNA-methyltranferase (MGMT), a DNA repair protein implicated in the resistance to temozolomide, was studied in only 10 out of these 16 patients. It has been suggested that low expression of MGMT could predict temozolomide efficacy.Objective: The aim of this st...